Research Publications
Author contribution key: *co-first authors; §co-second authors; ‡corresponding author
18. 2023 | Nature Communications | Fame R.M., Kalugin P.N., Petrova B., Xu H., Soden P.A., Shipley F.B., Dani N., Grant B., Pragana A., Head J.P., Gupta S., Shannon M.L., Chifamba F.F., Hawks-Mayer H., Vernon A., Gao F., Zhang Y., Holtzman M.J., Heiman M., Andermann M.L., Kanarek N., Lipton J.O., Lehtinen M.K. Diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution.
17. 2023 | Fluids and Barriers of the CNS | Fame R.M.*, Xu H.*, Pragana A., Lehtinen M.K Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1.
16. 2023 | Neuron | Sadegh C*, Xu H*, Sutin J, Fatou B, Gupta S, Pragana A, Taylor M, Kalugin PM, Zawadzki ME, Alturkistani O, Shipley FB, Dani N, Fame RM, Wurie Z, Talati P, Schleicher RL, Klein EM, Zhang Y, Holtzman MJ, Moore CI, Lin P-Y, Patel AB, Warf BC, Kimberly WT, Steen H, Andermann ML, Lehtinen MK. Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus.
15. 2021 | Nature Communications | Xu H*, Fame RM*, Sadegh C, Sutin J, Naranjo C, Syau D, Cui J, Shipley FB, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Warf BC, Lin P-Y, and Lehtinen MK. Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development.
14. 2021 | Development | Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, and Bryja V. MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus.
13. 2022 | Cell Death & Differentiation | Li Q, Han Z, Singh N, Terré N, Fame RM, Arif U, Page TD, Zahran T, Abdeltawab A, Huang Y, CaoP, Wang J, L, H, Lidov HGW, Surendra, K, Wu L, Schüller U, Wechsler-Reya RJ, Lehtinen MK, Liu Z, Stracker TH, Zhao H. Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.
12. 2020 | Neuron | Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang, E, Klein, EM, Goldey, GJ, He, K, Zhang, Y, Holtzman, MJ, Kirchhausen, T, Wyart, C, Moore, CI, Andermann ML, and Lehtinen MK. Tracking calcium dynamics and immune surveillance at the choroid plexus blood-cerebrospinal fluid interface.
11. 2019 | Development | Fame RM, Shannon ML, Chau FK, Head JP, Lehtinen MK. A concerted metabolic shift in early forebrain alters the CSF proteome and depends on cMYC downregulation for mitochondrial maturation.
10. 2019 | Cell | Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.
9. 2018 | eLife | Chau FK, Shannon ML, Fame RM, Fonseca E, Mullan H, Johnson MB, Sendamarai A, Springel MW, Laurent B, Lehtinen MK. Downregulation of ribosome biogenesis during early forebrain development.
8. 2018 | American Journal of Pathology | Shannon ML*, Fame RM*, Chau KF*, Dani N, Calicchio ML, Géléoc GS, Lidov HGW, Alexandrescu S, Lehtinen MK. Mice expressing c-MYC in neural precursors develop choroid plexus and ciliary body tumors.
7. 2018 | eNeuro | MacDonald* JL, Fame RM*, Gillis-Buck EM, and Macklis JD. Caveolin 1 identifies a specific subpopulation of cerebral cortex callosal projection neurons (CPN) including dual projecting cortical callosal/frontal projection neurons (CPN/FPN).
6. 2017 | Cerebral Cortex | Fame RM, Dehay C, Kennedy H, and Macklis JD. Subtype-specific genes that characterize subpopulations of callosal projection neurons in mouse identify molecularly homologous populations in macaque cortex. Cerebral Cortex.
5. 2016 | Fluids and Barriers of the CNS | Fame RM, Chang JT, Hong A, Aponte-Santiago NA, and Sive H. Directional cerebrospinal fluid movement between embryonic brain ventricles.
4. 2016 | The Journal of Neuroscience | Fame RM*, MacDonald, JL*, Dunwoodie SL, Takahashi E, and Macklis JD. Cited2 regulates neocortical layer II/III generation and somatosensory callosal projection neuron development and connectivity.
3. 2009 | The Journal of Neuroscience | Molyneaux BJ*, Arlotta P*, Fame RM§, MacDonald JL§, MacQuarrie KL, and Macklis JD. Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons.
2. 2009 | Nature Neuroscience | Azim EA, Jabaudon D, Fame RM, and Macklis JD. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development.
1. 2006 | Neural Development | Fame RM, Brajon C., and Ghysen A. Second-order projection from the posterior lateral line in the early zebrafish brain.
Peer-reviewed Review papers
5. 2022 | Physiological reviews | Saunders, N. R., Dziegielewska, K. M., Fame, R. M., Lehtinen, M. K., Liddelow, S. A. The choroid plexus: a missing link in our understanding of brain development and function.
4. 2021 | Frontiers in Cell and Developmental Biology | Fame RM‡ and Lehtinen MK. Mitochondria in early forebrain development: neurulation to mid-corticogenesis.
3. 2020 | Bioessays | Fame RM, Cortés-Campos C, and Sive HL. Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube: A Primer with Latest Insights.
2. 2020 | Developmental Cell | Fame RM, and Lehtinen MK. Emergence and Developmental Roles of the Cerebrospinal Fluid System.
1. 2011 | Trends in Neuroscience | Fame RM*, MacDonald JL*, and Macklis JD. Development, specification, and diversity of callosal projection neurons.
Invited Book Chapters and Research Highlights
4. 2023 | The Oxford Handbook of Mitochondria. | Fame RM‡ and Lehtinen MK. Mitochondria in early forebrain development: neurulation to mid-corticogenesis. Editor: E Jonas. Oxford University Press.
3. 2022 | Cell | Fame, R. M. Cerebrovasculature pumps up progenitors.
2. Fame RM and Lehtinen MK. Sister, Sister: Ependymal Cells and Adult Neural Stem Cells Are Separated at Birth by Geminin Family Members. Neuron. 2019 Apr 17;102(2):278-279.
1. MacDonald JL*, Fame RM*, Azim E, Shnider SJ, Molyneaux BJ, Arlotta P, and Macklis JD. Specification of Cortical Projection Neurons Transcriptional Mechanisms, Editors: JLR Rubenstein and P Rakic;, In: Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS, Amsterdam: Academic Press, 2013, pp. 475-502.
- update: Ozkan, A, MacDonald, JL, Fame, RM, Itoh, Y, Peter, M, Durak, O, Macklis JD, Chapter 19 - Specification of Cortical Projection Neurons: Transcriptional Mechanisms, Editors: JLR Rubenstein, Pasko Rakic, B Chen, KY Kwan, In: Patterning and Cell Type Specification in the Developing CNS and PNS (2nd Edition), Academic Press, 2020, pp 427-459, ISBN 9780128144053. 
